Mikhail Blagosklonny Ideas on the role of TOR in Aging and Cancer

Mikhail Blagosklonny is an oncologist, author and a professor at Roswell Park Cancer Institute. He possesses vast knowledge in cancer, cellular, and molecular biology, as well as clinical investigations. His specialties include cell cycle, anticancer therapeutics, mitosis, tumor suppressors, and signal transductions among others. His involvement in the age-related diseases and aging has helped him reveal anti-aging drugs such as rapamycin. Mikhail Blagosklonny holds a Medical Doctorate in internal medicine from the First Pavlov State Medical University of St. Petersburg.

Career Background

Mikhail Blagosklonny has vast experience in the medical field on LinkedIn following his work at research and medical education institutions in the United Sates. In 2002, he worked at New York Medical College as an Associate Professor of Medicine. He later joined Ordway Research Institute in Albany New York as a Senior Scientist. He later got an appointment at Roswell Park Cancer Institute as an oncologist professor following his knowledge in the cancer biology and therapy. Additionally, Mikhail is an author of more than 170 research work, book chapters, and reviews.

Mikhail Blagosklonny is an editor of several publications of Cell Cycles, PLOS ONE, Cell Death and Differentiation, Autophagy, and Cancer Research as well as Cancer Biology and Therapy. He has also edited journals such as the American Journal of Pathology and International Journal of Cancer.

Rosewell Park Cancer Institute

Rosewell Park Cancer Institute is a New York-based medical facility that deals with cancer research and treatment on researchgate.net. The institution, which is a member of the National Comprehensive Cancer Network, carries out clinical research and develops new drugs for the treatment of different types of cancer in adults and children. Mikhail Blagosklonny’s role in the institution includes formulation of new anti-cancer therapies on Google.com, as well as various methods of preventing cancer. He also engages the fellow workmates in the institution in developing new ideas on normal cell protection during chemotherapy and radiotherapy.

Role of mTOR in Aging and Cancer

According to Mikhail Blagosklonny, molecular damage or any other random damage is not the primary cause of aging and cancer. He cites that the inflammatory activity of the hypothalamus that increases with age could be the cause of aging. The Target of Rapamycin (mTOR) promotes cellular mass growth, and when the developmental stage comes to a halt, the aging process begins. mTOR leads to increased functioning of the cell in the body leading to an increase in the secretion produced by fibroblasts that alter the normal equilibrium of the body. A change in the body’s balance leads to age-related diseases resulting to death.

Flavio Maluf: His Vision in Leadership

The professional trajectory of Flavio Maluf is brilliant. The Brazilian, Flavio Maluf, graduated with a bachelor’s degree in Mechanical Engineering from Armando Penteado Foundation University. For more than a year, he lived abroad studying and working as a business administrator at the University of New York.

In 1986, he got married to Jacqueline Torres. Their relationship bore them three children. The 22-year-old daughter is his first born. She graduated from the University of London with a bachelor’s degree in Chemical Engineering. Their 19-year-old daughter graduated from the University of Penteado Armando Foundation with a bachelor’s degree in Business Administration. The 15-year-old son is their last born child. He wants to follow the footsteps of his father. He is currently studying engineering at the University of London.

Flavio has worked in Eucatex Group of companies as from 1989. He started by working in the trade section of the company before trajecting to the top management seat. For many years, he worked at the manufacturing part. He made good use of his knowledge in engineering to provide solutions for the company in that section. Flavio was a talented individual in management. While he was working in the industry, his uncle extended an invitation to allow Flavio work under the administration of the company. In 1995, his uncle was the current president of the enterprise. After accruing a collaborative success, he was the only person in the company with a better vision to lead it to success. For this reason, the extended family running this business made a decision to make Flavio the next president of the company. He commenced his leadership by making innovative moves towards achieving new products.

When he assumed the presidential seat, he began modernization as a way to improve management. According to Flavio Maluf, he is an aggressive executive. However, he is not centralized in management. According to an interview carried out by embole.com.br, Flavio does not waste opportunities. For this reason, he is a professional planner who has dreams to achieve the best.

Eucatex Group History began in 1951. It was the first company to adopt environmental-friendly policies. The company uses eucalyptus trees to develop panels and plates.

Brown Modelling Agency Searches for the Best Talented Actors and Models in Austin and Dallas, Texas

Leading model and talent company, Brown Modelling Agency, in Austin, Texas is searching for the best actors and models in the area. The company built a strategic portfolio during its startup stage and features more than 100 new fresh talents, including women, men, and children. According to Mystatesman, across Central Texas, Brown Agency is continuously building its reputation and recently expanded, adding a new office in Dallas.

Brown Agency, formerly known as Wihelmina Austin was founded in 2010, by Justin Brown who now serves as CEO and President. The name was changed in 2015 as the result of a merger and acquisition transaction for Wihelmina to purchase Heyman Talent South, an Austin based acting agency. The merger between the two agencies created full-service talent company, Brown Modelling Agency to develop acting and modeling talents in Central Texas. Former founder of Heyman, Michael B. Bonne’ focuses on the theatrical part of the agency. Mr. Brown oversees everyday operations of the firm providing services to companies and corporations.

Brown Modelling Agency is presently searching for fresh faces, including actors and models in Austin and Dallas. Companies and corporations looking for talent in Texas, our portfolio composes of diversity of individuals, including age, gender, size and nationality. We provide talent services for commercials, films, fashion runway, videos, television, promotional events, and catalogue. Our agency is now recruiting men and women for theatrical and fashion; and men, women, and children for commercials. View our Instagram account for additional information.

FreedomPop Gains Ground as Solid Mobile Carrier

If seeing is believing than FreedomPop, the hot new freemium phone carrier, has just gotten a whole lot more popular. FreedomPop has been steadily rising in the ranks over the past couple of years as one of the top alternative mobile carriers around. What FreedomPop offers, and only they offer, is something that can’t be beaten: a completely free service. FreedomPop launched their ship and set their course by offering a core ‘freemium‘ service. The question that everyone is asking is this: Is FreedomPop worth it?


FreedomPop offers a completely free core service that provides 500 MB of mobile 4G data, unlimited texting, and up to 200 minutes of voice chat. If you are a minimalist phone user who just needs something to get by, well, this can’t really be beaten. CEO Stephen Stokols wanted to offer a mobile carrier to people that they could customize to their needs. People who choose to upgrade their service, while still staying on the affordable end of the spectrum, have found that FreedomPop is as competitive as anyone could be in the industry.


What is interesting about FreedomPop is that you can bring your own Sprint phone to the service and get your line going completely free. If you are satisfied with what FreedomPop offers in the core plan then you will never need to upgrade again. However, if you DO want more out of the program then there are a host of updates available to you. We’ll dig into our favorite service that FreedomPop offers: the unlimited $5 WiFi.


For the better part of the last year FreedomPop has been focusing on installing WiFi hotspots all over the country, hitting the major population centers the most. Through this effort there are now 10 million hot spots available for usage. For just $5 a month you can sign up for unlimited access to these spots in order to have protected, unlimited, WiFi at your fingertips. If you happen to live on one of these hot spots imagine the savings you’ll have instead of an internet bill!


FreedomPop’s main draw is that you can cater the service to your needs. To this end, what the company offers is an absolute slam dunk for people who are on a budget. Just about any FreedomPop review that you read will end up echoing these words; FreedomPop is whatever you make it out to be for your requirements.


Better Sales Marketing Skills Can Make All The Difference

One can make his or her business grow through applying many different strategies in order to develop one of the greatest methods is direct sales. Bernardo Chua is a successful direct sales businessman therefore a better entrepreneur, he is also the CEO of Organo Gold it’s a direct sales coffee corporate and products that provide to people who consume them, mostly the active business clients.

The expertise which he had in network marketing improved the development of the company, as the beneficiary of Napoleon Hill Foundation Gold Medal therefore contributing to the achievement of marketing industries.

Bernardo Chua as a well-known businessman has made him attain many awards including Dangal ng Bayar Award for business from People’s Choice and in the year 2014 he got National Consumers Quality Awards.

Many times his company was recognized as a direct selling food supply organization, he also partners with top people in Ganoderma producers in the world, thus increasing the features of the company’s produces.

Through his entire early growth in business, he was familiar with the significance of having a direct sales business, he decided to stretch his business to the Philippines and many other countries. According to The Street, Bernardo Chua knew about the well-known Ganoderma in which products of mushrooms that have developed to be the main produce in Organo Gold.

In the year 2006 Organo Gold was well recognized since being in the market for more than five years, it was declared to be the 55th biggest direct sales company worldwide. It has many suppliers who are more than one million in the world.

Each day the coffee manufacturing makes a struggle to stay on top of the charts, henceforth retaining its legacy. Organo Gold is situated in Canada in which it’s well-known to have tough rules in producers and enterprises, therefore adding the growth of the company since the quality of products they produce are good and certified also the company has made a healthy substitute to many others coffee which has better taste that improves the live hood of the society.

5 Benefits of Car Refinancing

Refinancing your car means replacing your current car loan with a new loan based on different terms. Usually, the new loan is gotten from a new lender who offers better interest. A lot of people are not aware that they can refinance their car or do not understand the process to do it but car refinancing is quite easy to do. You can directly apply online to an auto refinancing company and get a response within a day.


Benefits of Car Refinancing


There are several benefits to refinancing your car, some of them are:


1.) To lower your interest rate: Refinancing your car is the best way to lower your interest rate. If you previously had no credit score, you can refinance your car after a few years for a lower interest rate. With reduced interest, you will be able to pay off your car loan in a shorter time.


2.) To get money: Sometimes people refinance their cars to get money for other projects. If you owe less than your vehicle is worth, you can refinance for some spare cash. Let’s assume you own a 4-year old car currently worth $10000, and you owe $6000. The best thing to do is to refinance the vehicle for an $8000 loan. This way you still owe less than your car’s’ worth and have $2000 to use for something else.


3.) To lower your payment: A common question people ask about car loan is “what are some ways I can slash my payments?”. While there are several options, refinancing is by far one of the easiest. When you refinance, you have the choice of extending your car loan. So if you have two years of payment left, you can stretch it out to four years and reduce your expenses. Extending your payment period may affect your interest rate, but it will reduce your financial strain especially in times of emergency like medical expenses


4.) To change lenders: If your current lender is hard to get in touch with or not making your payment information available, refinancing can help you get a better lender that will attend to your needs more carefully.


5.) To Change the co-signer on your loan: Refinancing is an easy way to remove or add someone as a co-signer to your loan because it comes with a new contract. Adding a co-signer can be very helpful if you need help paying off a large loan.


What to do Before Car Refinancing


1.) Get to know your payoff amount and APR (annual percentage rate of charge) from your current lender.


2.) Prepare your vehicle information


4.) Find out if the value of your car is still at the same level so that you don’t end up paying more on your refinance than the car value.


5.) Find out the next time you need to make payment. In some cases, you can skip a month payment if you refinance early.


To save money on car loans check out Ignition Financial, a great refinance loan provider with the best the best rates and flexible payment terms to fit right into your budget.


4 Reasons Doe Deere Is On Top Of The Makeup Industry

She Is Living Her Dream

When Doe Deere was a small girl, she had a fixation on bright colors and expressing herself. Now thanks to Lime Crime, her makeup line she launched in 2008, Deere has actually made a career out of creativity. Millions of fans across the world look to her for the latest makeup to complete their collections. These fans aren’t flocking to Deere because they want to belong to the latest fad. She’s had this fandom since her early days as a Youtube celebrity.



She Protects The Lives Of Animals

While she has amassed a fairly large fortune, this has not stopped Deere from making animal welfare an important cause for her to pursue. In order to take a stand against animal cruelty in the cosmetics industry, Deere has made a vow to avoid using any animal byproducts in her makeup. Just she herself is a vegan, everything produced by Lime Crime is vegan as well. Additionally, Doe Deere has made a habit of donating to charities devoted to helping shelter animals find homes and escape abusive pasts.



She Inspires Other Women In Business

The success of Doe Deere is incredible when viewed within context. During the mid 2000s, she emerged as one of the first web celebrities and established her own makeup line shortly after. In business, the majority of attempts simply are not successful and the few success stories are seldom experimental. Deere’s pioneering not only proves an exception to this rule, it provides proof that young women can succeed in business if they decide to commit themselves to it. To help other women start their own businesses, Deere regularly gives speeches at events encouraging and sponsoring young women in entrepreneurship.



She Continues To Find New Ideas

Currently, Deere is an incredibly successful entrepreneur who could easily retire with millions in her bank account, However, she refuses to give up and continues to find new ideas for product line. She routinely releases new lipsticks, mascaras, and blushes for her fans to enjoy and purchase. In an effort to expand her customer base Deere has made an effort to increase her social media presence and invites her fans to follow her various social media accounts. Although she was one of the first web celebrities to reach this far, she has not fooled herself into believing she does not need to continue her hard work.



Sam Tabar’s Advice To Parents

Sam Tabar is a graduate of Oxford University. He pursued a Master’s degree in Law at Columbia University and graduated in the year 2001. He then went to the New York Bar Association.

He began his career in 2001 as a Managing Director at the Sparx Group, handling Business plans, capital management, and legal affairs for ten years. He was also an attorney at Skadden Arps Slate, Meagher & Flom LLP & Affiliates between 2001 and 2007.

In 2011,Sam Tabar worked for Head of Capital Strategy as the Director. He restarted his legal career as a Senior Associate at Schukte Roth & Zabel LLP until 2014.

Sam is currently the Chief Operating Officer of Full Cycle Fund in 2015 and the Chief Financial Officer at Awearable Apparel.

Sam Tabar has recently written an article expressing his views on when a parent should cease supporting their child’s livelihood.

He revealed that survey by Fidelity states that 47% of millennial youth aged 25 to 35 managed their new livelihood with support from their parents. Their parents mainly catered for their telephone bills with 21% contribution. Groceries had a 20% help, clothing had a 16% aid, entertained had a 14% help while rent and mortgage had a 12% support.

He explained that the statistics are a thoughtful reflection of a parent’s concern for their child’s comfort, hence ensuring that the child lives in a secure location.

However, with time, the parent may begin to wonder when they should stop chipping in.

He continued to add that Federal Reserve researched that millennials are a step further in future planning than the previous generations. Statistics recorded show that an average American has a saving of $400 while a millennial has a saving of $2100.He complimented the vision of the millennials, but questioned the condition of the parents who are enabling them to achieve such high savings.

He concluded that since most adults have less than $400 in savings, an excessively supporting parent will create a dent in their retirement funds. He also noted that a small percentage of parents have taken into account their retirement plan, hence only support their children as much as necessary.

Sam continued to write that parents should strive to be open enough to their children about the need for selective spending. He advised parents to consider their retirement as well as the financial ability of the child. According to Sam, if a child is financially able to pay their bills, they should minimize the total amount spent by cutting down on unnecessary costs.

Tabar is noted that taking parental support may financially destabilize the child for a while. However, if the child has enough savings, they will recover in time.

Don’t Be Fooled By Other Companies, FreedomPop Has The Best Services And Prices

It’s no wonder why so many people have tired of the same phone companies, it’s because of the fact that many of them are only making changes for the worse and not for better. How does it pay off to higher the prices of cell phone services that haven’t gotten any better? FreedomPop is going the opposite way by lowering the prices for cell phone services, especially the unlimited everything plan that has been around for a while and has only become more popular. Almost every cell phone company out there has some type of unlimited phone plan, even if it includes unlimited data or not.


Most people prefer to have unlimited plans because gives them all the data that they want and need, but some phone companies charge a hefty price for it. Examine a FreedomPop review that includes info about unlimited data in their unlimited everything plan for only $19.99, and the plan even comes with 1 GB of the 4G LTE data as well. With unlimited talk and text also been included in the plan, what’s not to love about it? There is even a plan that costs even less and still has unlimited services, which is the $10.99 plan with unlimited talk and text and 500 MB of data.


One can save more by going on the free plan that has unlimited text messages, 200 minutes of talk time, and 500 MB of data. With different ways to get extra data, there’s never any to worry because it can be bought or earned. FreedomPop has made available to the public different surveys and offers that can be completed to gain extra data. It’s typical for 10 MB of data to be given for every offer that’s completed, and anyone who wants to add a friend or family member as a FreedomPop customer will gain data as well.


There is also the option of simply paying for data at only two cents per megabyte, but this option may not be good for someone who knows they’ll be using a lot of data. Choose to get the Wi-Fi service from FreedomPop for five dollars per month, which is available in millions of hotspots and gives unlimited 3G and 4G Internet services. Those with the capability of using Wi-Fi services to make calls and more their cell phone can use the Wi-Fi services, which means they’ll have a complete phone service through Wi-Fi.